Parkinson's disease is a degenerative disorder of the central nervous system mainly affecting the motor system. The motor symptoms of Parkinson's disease result from the death of dopamine generating cells in the substantia nigra a region of the midbrain. The causes of this cell death are poorly understood. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, and depression is the most common psychiatric symptom Other symptoms include sensory, sleep and emotional problems. Parkinson's disease is more common in older people, with most cases occurring after the age of 50; when it is seen in young adults, it is called young onset PD (YOPD).
The main motor symptoms are collectively called parkinsonism, or a "parkinsonian syndrome". The disease can be either primary or secondary. Primary Parkinson's disease is referred to as idiopathic (having no known cause), although some atypical cases have a genetic origin, while secondary parkinsonism is due to known causes like toxins. Many risks and protective factors have been investigated: the clearest evidence is for an increased risk of PD in people exposed to certain pesticides and a reduced risk in tobacco smokers. The pathology of the disease is characterized by the accumulation of a protein into Lewy bodies in neurons, and insufficient formation and activity of dopamine in certain parts of the midbrain. Where the Lewy bodies are located is often related to the expression and degree of the symptoms of an individual. Diagnosis of typical cases is mainly based on symptoms, with tests such as neuroimaging being used for confirmation.
AGARICUS MUS. 200-CM- Jerking , trembling and stiffness of  the muscles. Spine cannot even bear to touch
GELSEMIUM  30-CM—There is trembling of the head and other parts of the body. Staggering gait.Trembling is the chief indication for the use of this remedy
ARGENTUM NITRICUM 200-CM- Use it with Gelsemium on alternate days, when the memory is also impaired with spurting diarrhea and flatulence
AVENA SAATIVA  Q- Best tonic for debility after exhausting disease , nervous exhaustion and paralysis agitans. Give 20 drops thrice daily in warm water
CAUSTICUM 200-CM- Unsteadiness of the muscles of forearm and hand. Numbness. Loss of sensation of hands
CURARE 200—Reflexes lessened or abolished in extremities. Weakness of hands and fingers , cannot lift the fingers
HELODERMA 200—Parkinson’s disease affecting the left side mostly with the feeling of prostration and coldness
MAGNESIUM PHOS  1M—Involuntary shaking of the hand. Give it weekly
PHYSOSTIGMA 200- Muscular weakness is felt more on movement and in winter. Palpitation of the heart is felt throughout the body
STRAMONIUM 200- CM—Parkinsonism. Tremor, muscular weaknessd rigidity. Peculiar gait and shaking

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