GENE RESPONSIBLE FOR TRAITS INVOLVED IN DIABETES DISCOVERED
A collaborative
research team led by Medical College of Wisconsin (MCW) scientists has
identified a new gene associated with fasting glucose and insulin levels in
rats, mice and in humans. The findings are published in the September issue of Genetics.
Leah Solberg Woods,
Ph.D., associate professor of pediatrics at MCW and a researcher in the
Children's Hospital of Wisconsin Research Institute, led the study and is the
corresponding author of the paper.
The authors of the
paper identified a gene called Tpcn2 in which a variant was associated with
fasting glucose levels in a rat model. Studies in Tpcn2 knockout mice also
demonstrated the difference in fasting glucose levels as well as insulin
response between the knockout animals and regular mice. Finally, Dr. Woods'
team identified variants within Tpcn2 associated with fasting insulin in
humans. Tpcn2 is a lysosomal calcium channel that likely plays a role in
insulin signaling. Glucose tolerance, insulin resistance and beta cell
dysfunction are key underlying causes of type 2 diabetes.
"Genome-wide
association studies in humans have identified 60+ genes linked to type 2
diabetes; however, these genes explain only a small portion of heritability in
diabetes studies. As we continue to identify genes and variants of interest, we
will evaluate them in multiple models to understand the mechanism of
disease," said Dr. Solberg Woods.
According to the
American Diabetes Association, 29 million Americans have diabetes -- more than
nine percent of the total population. It is the 7th leading cause of death, and
experts estimate diabetes is an underreported cause of death because of the
comorbidities and complications associated with the disease.
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