EXTREME LONGEVITY, NO GENES SIGNIFICANTLY LINKED

-
Using fewer than twenty genomes, researchers were unable to find rare protein-altering variants significantly associated with extreme longevity, according to a study published November 12, 2014 in the open-access journal PLOS ONE by Hinco Gierman from Stanford University and colleagues
Supercentenarians are the world's oldest people, living beyond 110 years of age. Seventy-four are alive worldwide, with twenty-two living in the United States. The authors of this study performed whole-genome sequencing on 17 supercentenarians to explore the genetic basis underlying extreme human longevity.
From this small sample size, the researchers were unable to find rare protein-altering variants significantly associated with extreme longevity compared to control genomes. However, they did find that one supercentenarian carries a variant associated with a heart condition, which had little or no effect on his/her health, as this person lived over 110 years.
The authors added that it is recommended by the American College of Medical Genetics and Genomics to report the results to this individual as an incidental finding. Although the authors didn't find significant association with extreme longevity, the authors have publicly published the genomes, making them available as a resource for future studies on the genetic basis of extreme longevity.
This work was supported by the Ellison Medical Foundation/American Federation for Aging Research Fellowship, Stanford Dean's Fellowship, The Paul Glenn Foundation Biology of Aging Seed Grant, National Institute of General Medical Sciences Center for Systems Biology (P50 GM076547) and the University of Luxembourg - Institute for Systems Biology Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Comments

Post a Comment

Popular posts from this blog

EASY PRESCRIBER 2ND EDITION

-
Image
EASY PRESCRIBER 2 ND EDITION OF THE BEST-SELLER Author: Dr. K S Gopi, BSc, BHMS, MD. Former Professor Govt. Homoeopathic Medical College Kozhikode, Kerala. India. SALIENT FEATURES ·        More additions, including Covid-19, and more psychiatric diseases ·        A practical guide for practitioners and medical students. ·        Includes almost all disease conditions and their Homeopathic Management ·        Special arrangement of medicines will help easy selection of remedy and potency. ·        Dose and repetition of dose is clearly mentioned in each disease ·        Crown ¼ size, 980 pages, doble colour printing and hard bound, PRICE: Rs .2250 (India), $ 100 FOR COPIES CONTACT - email-plantmedicines@yahoo.com, WhatsApp-+919207011814, Amazon.in, Homeomart.com  
Read more

HOMOEOPATHIC REMEDIES FOR DE QUERVAIN'S TENOSYNOVITIS

-
Image
De Quervain's tenosynovitis  is a painful condition affecting the tendons on the thumb side of your wrist. If you have de Quervain's tenosynovitis, it will probably hurt when you turn your wrist, grasp anything or make a fist. Although the exact cause of de Quervain's tenosynovitis isn't known, any activity that relies on repetitive hand or wrist movement — such as working in the garden, playing golf or racket sports, or lifting your baby — can make it worse. Causes- Chronic overuse of your wrist is commonly associated with de Quervain's tenosynovitis. Tendons are rope-like structures that attach muscle to bone. When you grip, grasp, clench, pinch or wring anything in your hand, two tendons in your wrist and lower thumb normally glide smoothly through the small tunnel that connects them to the base of the thumb. Repeating a particular motion day after day may irritate the sheath around the two tendons, causing thickening and swelling that restricts their m...
Read more

HOMOEOPATHIC REMEDIES FOR IMPETIGO

-
Image
Impetigo  is a common and highly contagious skin infection that mainly affects infants and children. Impetigo usually appears as red sores on the face, especially around a child's nose and mouth, and on hands and feet. The sores burst and develop honey-colored crusts. Causes - Impetigo is most often caused by staphylococcus aureus. Non –bullous impetigo can also be caused by group A beta-haemolytic streptococcus, Streptococcus pyogenes. The  bacteria that cause impetigo when you come into contact with the sores of someone who's infected or with items they've touched — such as clothing, bed linen, towels and even toys. Symptoms - Classic signs and symptoms of impetigo involve red sores that quickly rupture, ooze for a few days and then form a yellowish-brown crust. The sores usually occur around the nose and mouth but can be spread to other areas of the body by fingers, clothing and towels. Itching and soreness are generally mild. A less common form of the disorder...
Read more