REPRODUCTION LATER IN LIFE IS A MARKER FOR LONGEVITY IN WOMEN
Women who are able to
naturally have children later in life tend to live longer and the genetic
variants that allow them to do so might also facilitate exceptionally long life
spans.
Boston
University School of Medicine (BUSM) study published in Menopause: The
Journal of the North American Menopause Society, says women who are able to
have children after the age of 33 have a greater chance of living longer than
women who had their last child before the age of 30.
"Of course this
does not mean women should wait to have children at older ages in order to
improve their own chances of living longer," explained corresponding
author Thomas Perls, MD, MPH. "The age at last childbirth can be a rate of
aging indicator. The natural ability to have a child at an older age likely
indicates that a woman's reproductive system is aging slowly, and therefore so
is the rest of her body."
The study was based on
analysis of data from the Long Life Family Study (LLFS) -- a biopsychosocial
and genetic study of 551 families with many members living to exceptionally old
ages. Boston Medical Center, the teaching hospital affiliate of BUSM, is one of
four study centers that make up the LLFS. The study investigators determined
the ages at which 462 women had their last child and how old those women lived
to be. The research found that women who had their last child after the age of
33 years had twice the odds of living to 95 years or older compared with women
who had their last child by age 29.
The findings also
indicate that women may be the driving force behind the evolution of genetic
variants that slow aging and decrease risk for age-related genes, which help
people live to extreme old age.
"If a woman has
those variants, she is able to reproduce and bear children for a longer period
of time, increasing her chances of passing down those genes to the next
generation," said Perls, the director of the New England Centenarian Study
(NECS), a principal investigator of the LLFS and a professor of medicine at
BUSM. "This possibility may be a clue as to why 85 percent of women live
to 100 or more years while only 15 percent of men do."
The results of this
study are consistent with other findings on the relationship between maternal
age at birth of last child and exceptional longevity. Previously, the NECS
found that women who gave birth to a child after the age of 40 were four times
more likely to live to 100 than women who had their last child at a younger
age.
The results of Perls'
study show the importance of future research on the genetic influences of
reproductive fitness because they may also impact a person's rate of aging and
susceptibility to age-related diseases, according to the researchers.
The study,
"Extended maternal age at birth of last child and women's longevity in the
Long Life Family Study," will be published in the January 2015 print
edition of Menopause.
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