FERTILITY HOPE FOR CHILD CANCER SURVIVORS
Girls with cancer who are most likely to become
infertile after treatment can be identified using guidelines developed almost
20 years ago, new research shows
The criteria --
developed in Edinburgh -- will help to select which girls should be offered the
opportunity to freeze some tissue from their ovaries for use in the future.
Doctors are
optimistic that the frozen tissue could one day help young cancer survivors to
have children of their own.
Some cancer
treatments can affect female fertility by bringing on early menopause. Freezing
samples of ovary tissue before patients start treatment is the only option to
try to preserve their fertility.
At least 30 babies
have been born from frozen ovarian tissue taken from adult women but the
procedure remains unproven in girls and young women.
Taking the initial
samples of ovaries to be frozen involves a surgical technique and is still
relatively experimental. It is therefore crucial that doctors can accurately
predict which patients are most likely to benefit and when it can be safely
performed.
Guidelines were
developed almost 20 years ago to select which girls should be offered the
procedure, based on their age, type of cancer treatment and their chances of
being cured of their cancer. Now that the girls are older, doctors are able to
validate their predictions.
Researchers -- led
by the University of Edinburgh -- validated the criteria by looking back at
more than 400 girls with cancer who were under 18 years of age when diagnosed.
They found that the criteria accurately predicted all but one of the patients
who entered early menopause.
The study, funded by
the Medical Research Council, is published in the journal Lancet
Oncology.
The lead researcher
is Professor Hamish Wallace of the University of Edinburgh's Department of
Child Life and Health and Consultant Paediatric Oncologist at the Royal
Hospital for Sick Children (RHSC), where the research was carried out. He said:
"Advances in lifesaving treatments mean that more and more young people
with cancer are surviving the disease. Here we have an opportunity to help
young women to have families of their own when they grow up, if they so
choose."
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