COMMON DIABETES DRUG CAN REDUCE BAD CHOLESTEROL

-
A common diabetes drug Metformin can also help lower “bad” cholesterol that is known for promoting cardiovascular diseases by hardening the arteries, significant research has found.
“The findings suggest that Metformin might indeed have an additional beneficial effect with regards to cardiovascular diseases among the diabetes patients”, said study first author Dr Tao Xu from Helmholtz Zentrum Minchen, the German research centre for environment health in Neuherberg.
Along with the team from the German Diabetes Centre (DDZ) in Dusseldorf, Dr Tu and colleagues analysed more than 1,800 blood samples of participants.
Using a comprehensive approach, the scientists investigated metabolic products (metabolites) as well as genetics of these participants.
They found that the administration of Metformin in patients suffering from Type 2 Diabetes led to a change in metabolite levels.
According to the authors, this was associated with a significantly decreased level of LDL or “bad” cholesterol.
The researchers speculate that Metformin intake affects the levels of LDL cholesterol, leading to a down-regulation of specific genes.
“This is also supported by the fact that three lipid metabolites are decreased after taking the diabetes drug. Presumably, this is the mechanism how the production of ‘LDL’ cholesterol is repressed by Metformin,” explained
Dr Rui Wang-Sattler from the institute of epidemiology II of the Helmholtz Zentrum Minchen.
“Until now the exact mechanism is unclear. Thus, we want to continue our contribution to its decryption”, added co-study author Dr Stefan Brandmaier in a paper published in the journal Diabetes Care.
Metformin is the oldest and most frequently used oral anti-diabetes drug.
It affects blood fat levels via AMPK signalling pathway. The AMP activated protein kinase (AMPK) is an enzyme that determines the energy status of the cell.

In case, the energy status is low, AMPK stops energy consuming processes like the synthesis of cholesterol or fatty acids.

Comments

Post a Comment

Popular posts from this blog

EASY PRESCRIBER 2ND EDITION

-
Image
EASY PRESCRIBER 2 ND EDITION OF THE BEST-SELLER Author: Dr. K S Gopi, BSc, BHMS, MD. Former Professor Govt. Homoeopathic Medical College Kozhikode, Kerala. India. SALIENT FEATURES ·        More additions, including Covid-19, and more psychiatric diseases ·        A practical guide for practitioners and medical students. ·        Includes almost all disease conditions and their Homeopathic Management ·        Special arrangement of medicines will help easy selection of remedy and potency. ·        Dose and repetition of dose is clearly mentioned in each disease ·        Crown ¼ size, 980 pages, doble colour printing and hard bound, PRICE: Rs .2250 (India), $ 100 FOR COPIES CONTACT - email-plantmedicines@yahoo.com, WhatsApp-+919207011814, Amazon.in, Homeomart.com  
Read more

HOMOEOPATHIC REMEDIES FOR DE QUERVAIN'S TENOSYNOVITIS

-
Image
De Quervain's tenosynovitis  is a painful condition affecting the tendons on the thumb side of your wrist. If you have de Quervain's tenosynovitis, it will probably hurt when you turn your wrist, grasp anything or make a fist. Although the exact cause of de Quervain's tenosynovitis isn't known, any activity that relies on repetitive hand or wrist movement — such as working in the garden, playing golf or racket sports, or lifting your baby — can make it worse. Causes- Chronic overuse of your wrist is commonly associated with de Quervain's tenosynovitis. Tendons are rope-like structures that attach muscle to bone. When you grip, grasp, clench, pinch or wring anything in your hand, two tendons in your wrist and lower thumb normally glide smoothly through the small tunnel that connects them to the base of the thumb. Repeating a particular motion day after day may irritate the sheath around the two tendons, causing thickening and swelling that restricts their m...
Read more

HOMOEOPATHIC REMEDIES FOR IMPETIGO

-
Image
Impetigo  is a common and highly contagious skin infection that mainly affects infants and children. Impetigo usually appears as red sores on the face, especially around a child's nose and mouth, and on hands and feet. The sores burst and develop honey-colored crusts. Causes - Impetigo is most often caused by staphylococcus aureus. Non –bullous impetigo can also be caused by group A beta-haemolytic streptococcus, Streptococcus pyogenes. The  bacteria that cause impetigo when you come into contact with the sores of someone who's infected or with items they've touched — such as clothing, bed linen, towels and even toys. Symptoms - Classic signs and symptoms of impetigo involve red sores that quickly rupture, ooze for a few days and then form a yellowish-brown crust. The sores usually occur around the nose and mouth but can be spread to other areas of the body by fingers, clothing and towels. Itching and soreness are generally mild. A less common form of the disorder...
Read more