SINGLE DOSE DRUG TO TREAT INFLUENZA
There could soon be a single dose therapy to treat influenza in the US.
Researchers have found a single injected dose of the neuraminidase inhibitor (NAI) Peramivir to be safe and effective at alleviating influenza symptoms.
It can palliate symptoms, including fever and viral shedding, when administered within 48 hours of the onset of symptoms, an analysis of phase 2 and phase 3 clinical trials showed.
"Based on clinical data, Peramivir is the first neuraminidase inhibitor (NAI) that has shown to be safe and effective as a single dose therapy for patients with acute, uncomplicated influenza," said Rich Whitley from the University of Alabama, Birmingham in the US.
In two placebo controlled studies (one Phase 2 and one Phase 3), involving a combined 427 adults, a single dose of Peramivir was given as an injection within 48 hours of the onset of flu-like symptoms.
Peramivir was found to be generally safe and well tolerated and effectively reduced the duration of symptoms in Peramivir-treated patients.